TABLE 5.

Univariate logistic regression analysis of factors affecting the probability of clinical cure/improvement by combination therapy (n = 95)

Variablea	Coefficient	SE	P value	Odds ratio
				Estimate	95% CIb
WT	−0.016	0.021	0.45	0.99	0.95-1.03
Age	0.002	0.013	0.89	1.00	0.98-1.03
Sex	0.317	0.575	0.58	1.37	0.44-4.24
CLCR	0.002	0.004	0.56	1.00	1.00-1.01
Pneumonia	0.926	0.540	0.087	2.52	0.88-7.28
Sepsis	−1.515	0.633	0.017	0.22	0.06-0.76
Antifungal	−0.565	0.657	0.39	0.57	0.16-2.06
Cmaxc	−0.388	0.700	0.58	0.68	0.17-2.67
Cminc	−0.175	0.298	0.56	0.84	0.47-1.51
AUC0-24c	0.007	0.499	0.99	1.01	0.38-2.68
AUCcumc	0.194	0.403	0.63	1.21	0.55-2.68
First-Cmaxc	−0.483	0.554	0.38	0.62	0.21-1.83
MICc,d	−0.304	0.337	0.37	0.74	0.38-1.43
Cmax/MICc,d	0.269	0.331	0.42	1.31	0.68-2.51
AUC0-24/MICc,d	0.344	0.309	0.27	1.41	0.77-2.59
First-Cmax/MICc,d	0.159	0.299	0.59	1.17	0.65-2.11
Cmax/MIC > 25d,e	2.18		0.02	8.86	1.32-∞
AUC0-24/MIC > 186d,e	2.18		0.02	8.86	1.32-∞

^aAbbreviations are described in footnotes a of Tables 2 and 3.

^b95% CI, 95% confidence interval.

^cThese values were transformed (natural logarithmic transformation).

^dAnalysis was conducted for 57 patients whose MIC was measured.

^eVariable was categorized by the breakpoint, and exact logistic analysis was used.