TABLE 3.

Hypothesis testing for factors affecting pharmacokinetics of arbekacin

Question	Model compared	OBJ	ΔOBJ (−2l.l.d.)a	P value
	Full modelb	2,949.705
Is CL proportional to CLCR?
CLCR < 80 ml/min	Full model vs θ1 = 0	3,094.280	144.575	<0.001
CLCR ≥ 80 ml/min	Full model vs θ5 = 0	2,963.974	14.269	<0.001
Is CL proportional to patient WT? (CLCR ≥ 80 ml/min)	Full model vs θ6 = 0	2,968.591	18.886	<0.001
Is CL inversely proportional to age?	Full model vs θ7 = 0	2,971.777	22.072	<0.001
Do patients with pneumonia or sepsis have different V1 values?	Full model vs θ8 = 1	3,006.228	56.523	<0.001
Do patients with other infections have different V1 values?	Full model vs θ9 = 1	2,969.434	19.729	<0.001
	Full model vs θ9 = θ8	2,954.717	5.012	0.025
Do elderly people have different V1 values?	Full model vs θ10 = 1	2,955.665	5.960	0.014
Do patients with infectious diseases other than pneumonia have different V2 values?	Full model vs θ11 = 1	2,972.816	23.111	<0.001
Do patients with pneumonia have different V2 values?	Full model vs θ12 = 1	2,953.524	3.819	0.05
	Full model vs θ12 = θ11	2,966.097	16.392	<0.001

^a−2l.l.d., −2(log likelihood difference).

^bCL = θ₁CL_CR + (θ₇/age) (CL_CR < 80 ml/min), CL = θ₅CL_CR + θ₆WT + (θ₇/age) (CL_CR ≥ 80 ml/min) V_{1 healthy} = θ₂WT, V₁ = θ₈V_{1 healthy} (pneumonia or sepsis), V₁ = θ₉V_{1 healthy} (infections other than pneumonia and sepsis), V_{1 elderly} = θ₁₀V_{1 nonelderly}, V_{2 healthy} = θ₃, V₂ = θ₁₁V_{2 healthy} (except pneumonia), V₂ = θ₁₂V_{2 healthy} (pneumonia), Q = θ₄.