TABLE 5.
Bootstrap validation of the estimated population pharmacokinetic parameters in the final model
| Parametera | Final model estimate (95% CI)b | Bootstrap meanc (95% CI) | Difference (%)d |
|---|---|---|---|
| θ1 | 0.0319 (0.021-0.043) | 0.0322 (0.021-0.045) | 0.85 |
| θ2 | 0.17 (0.153-0.187) | 0.167 (0.146-0.187) | −2.0 |
| θ3 | 15.7 (12.1-19.3) | 14.9 (8.99-20.3) | −5.1 |
| θ4 | 3.84 (3.07-4.61) | 4.01 (3.08-6.35) | 4.3 |
| θ5 | 0.013 (0.0013-0.0247) | 0.0123 (0.0014-0.0242) | −5.1 |
| θ6 | 0.0342 (0.0042-0.0642) | 0.0362 (0.0062-0.0639) | 5.8 |
| θ7 | 26.5 (3.57-49.0) | 27 (6.16-53.3) | 1.9 |
| θ8 | 1.6 (1.42-1.78) | 1.62 (1.44-1.89) | 1.2 |
| θ9 | 1.4 (1.20-1.60) | 1.43 (1.22-1.70) | 1.9 |
| θ10 | 1.19 (1.01-1.38) | 1.17 (0.75-1.36) | −1.7 |
| θ11 | 1.55 (1.08-2.02) | 1.81 (1.04-4.32) | 16.0 |
| θ12 | 3.22 (2.36-4.08) | 3.1 (1.21-4.71) | −3.9 |
| ω12 | 0.151 (0.082-0.220) | 0.152 (0.084-0.236) | 0.91 |
| ω22 | 0.138 (0.102-0.174) | 0.142 (0.103-0.220) | 3.1 |
| ω32 | 2.71 (0.20-5.22) | 2.72 (0.022-6.61) | 0.39 |
| σ2 | 1.15 (0.74-1.56) | 1.12 (0.70-1.54) | −2.5 |
a
θs are the population mean parameters. Refer to the footnote of Table 3 for the denotation of each θ parameter.
b
95% CI, 95% confidence interval.
c
Mean of 200 bootstrap repetitions.
d
The difference between the final model estimate and bootstrap mean is calculated as follows: [(bootstrap mean − final model estimate)/final model estimate] × 100.