FIG. 2.

Graphics show inhibition of Pyr analogs. (A) Correlation of IC₅₀s derived from bacterial complementation assay and in vitro culture of P. falciparum assay. (B) Relationship between IC₅₀s obtained from cell-based assay systems (either parasite [square] or bacteria [triangle]) and the K_i values from the in vitro enzyme inhibition assay. Closed and open symbols are data points derived from the wild type and the mutant, respectively (data with K_i values and IC₅₀s greater than 60 nM and 50 μM were excluded from the plot). Each data point is the average from at least three independent experiments (each performed in triplicate).