TABLE 1.

Efficacy endpoints for WHO classification

Endpoint	Criteria
	Day 14 follow-up	Day 28 follow-up
Early treatment failure	Parasite density on day 2 > that on day 0, parasite density on day 3 ≥ 25% that on day 0, fever in the presence of parasites on day 3, or severe malaria in the presence of parasites on days 1-3	Parasite density on day 2 > that on day 0, parasite density on day 3 ≥ 25% that on day 0, fever in the presence of parasites on day 3, or severe malaria in the presence of parasites on days 1-3
Late clinical failure	Fever in the presence of parasites between days 4 and 14 or severe malaria in the presence of parasites between days 4 and 14	Fever in the presence of parasites between days 4 and 28 or severe malaria in the presence of parasites between days 4 and 28
Late parasitological failure	Parasites without fever on day 14	Parasites without fever on day 28
ACPR	Follow-up completed without meeting any of the above criteria	Follow-up completed without meeting any of the above criteria