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. 2006 Aug 28;50(11):3658–3664. doi: 10.1128/AAC.01087-05

TABLE 5.

Relationship of MIC and in vivo efficacy in the mouse thigh model for NCE ABI-0043

S. aureus strain Mutation MIC Lowest ED (mg/kg)a Lowest ED/MICa
29213 None 0.002 0.06 30
ABS-052 A477→D 0.5 10 20
ABS-100 H481→Y 2 >160 >80
a

The lowest ED is the dose (mouse thigh) resulting in a 1-log difference in bacterial titer compared with placebo-treated animals.