Table 1.

Summary of the five variants of BLAST considered in this study

Program	Scoring adjustment	Unified P-values
B-BLAST	None	No
S-BLAST	Compositional Scaling	No
C-BLAST	Compositional Adjustment	No
SU-BLAST	Compositional Scaling	Yes
CU-BLAST	Compositional Adjustment	Yes

Compositional Scaling refers to the method in (2) and Compositional Adjustment refers to the method in (15).