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Schematic comparison of GRIP domain-containing proteins. The shaded box shows the location of the ∼50 residue GRIP domain; the remaining sequences show a high propensity for coiled-coil formation. GCC185 C-term. represents the 110 C-terminal amino acid fragment used in these studies as a GST-fusion and by others (as a His-tagged protein; Panic et al., 2003a). The C-terminal–most residues 1343–1684 were initially identified in the yeast two-hybrid screen.
