Table 3.

Metalloid sensitivity of yeast mutants lacking the Hog1p MAPK and the AP-1–like transcription factors Yap1p and Yap8p

Strain	MICa (mM)
	As(III)b	As(V)c	Sb(III)d
W303-1A (wild type)	1.20	6.00	15.0
yap1Δ	0.75	5.00	2.00
yap8Δ	0.20	1.00	10.0
yap1Δ yap8Δ	0.07	0.75	1.00
hog1Δ	0.30	6.00	0.50
hog1Δ yap8Δ	0.07	1.00	0.40
hog1Δ yap1Δ	0.20	5.00	0.20
hog1Δ yap1Δ yap8Δ	0.03	0.75	0.20

^a MIC is the concentration at which no growth was scored on glucose medium. MIC values were determined on the basis of three independent experiments with identical results.

^b Sodium arsenite.

^c Sodium arsenate.

^d Potassium antimonyl tartrate.