Table 3.
Metalloid sensitivity of yeast mutants lacking the Hog1p MAPK and the AP-1–like transcription factors Yap1p and Yap8p
| Strain | MICa (mM) | ||
|---|---|---|---|
| As(III)b | As(V)c | Sb(III)d | |
| W303-1A (wild type) | 1.20 | 6.00 | 15.0 |
| yap1Δ | 0.75 | 5.00 | 2.00 |
| yap8Δ | 0.20 | 1.00 | 10.0 |
| yap1Δ yap8Δ | 0.07 | 0.75 | 1.00 |
| hog1Δ | 0.30 | 6.00 | 0.50 |
| hog1Δ yap8Δ | 0.07 | 1.00 | 0.40 |
| hog1Δ yap1Δ | 0.20 | 5.00 | 0.20 |
| hog1Δ yap1Δ yap8Δ | 0.03 | 0.75 | 0.20 |
a MIC is the concentration at which no growth was scored on glucose medium. MIC values were determined on the basis of three independent experiments with identical results.
b Sodium arsenite.
c Sodium arsenate.
d Potassium antimonyl tartrate.