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. 2006 Oct;17(10):4330–4342. doi: 10.1091/mbc.E06-02-0151

Figure 2.

Figure 2.

Reduced myelination of axons in sciatic nerves of 5-d-old AKO, EKO, and DKO mice. (A) Distribution of thicknesses of myelin sheaths in wild-type, AKO, EKO, and DKO sciatic nerves (WT, A, E, and D, respectively). n = 1370–2320 individual axons per genotype, as indicated below. (B) Bar diagram comparing the average sheath thickness (in nanometers, ± SEM). WT, 284.2 ± 3.0, n = 2320 sheaths; EKO, 232.6 ± 3.3, n = 1652; AKO, 251.7 ± 3.8, n = 1370; and DKO, 214.9 ± 5.4, n = 1601. All knockout means are distinct from WT mean (p < 0.0001); EKO and AKO means are distinct from DKO mean (EKO, *p = 0.0054); AKO, **p < 0.0001). Statistical significance was determined by Welch's t test. (C) Representative electron microscope pictures of transverse cross-sections through sciatic nerves of 5 d-old WT, AKO, EKO, and DKO mice. Arrows mark several cross-sections of myelinated axons, evident as closed dark figures. Arrowheads mark several unmyelinated axons.