Figure 5.

NGF-1 is the Neurospora homologue of the GCN5 histone acetyltransferase. Alignment of Neurospora NGF-1 (NcNGF1) with homologues from S. cerevisiae (ScGcn5), M. grisea (MgGCN5), and G. zeae (GzGCN5). Bold letters indicate identity among proteins. Mutations resulting in substitutions between wild-type NGF-1 and the predicted amino acid sequence of the mutant allele, ngf-1^RIP1, are indicated (+). Predicted nonsense codons are also shown (‡). Solid and dashed underlines indicate the catalytic HAT domain and bromodomain, respectively.