Figure 10.

Model for flow-mediated integrin suppression. For cells on collagen, onset of flow stimulates the junctional mechanoreceptor complex to trigger activation of integrin α2β1 through PI 3-kinase. Subsequent binding of integrins to collagen stimulates activation of PKA, which initiates a pathway that ultimately acts upon talin to suppress integrin αvβ3. For cells on FN or FG, onset of flow stimulates PI 3-kinase dependent activation of integrins α5β1 and αvβ3. Subsequent binding of these integrins to their ligands stimulates activation of PKCα, which initiates a pathway that ultimately acts upon talin to suppress integrin α2β1.