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(A) Ribbon representation of the mean structure of cycloviolacin O14. Cysteine residues and loops are labelled. (B) O14 (black thick line) is labelled and overlaid with kalata B1 (blue, PDB ID: 1NB1) and cycloviolacin O1 (red, PDB ID: 1NBJ). There is preservation of the defining structural features (the CCK motif) despite the sequence variations that cause changes in cytotoxic activity.
