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. 2006 Oct 27;400(Pt 1):63–73. doi: 10.1042/BJ20060848

Figure 7. Sulfs are major regulators of 6S within HS.

Figure 7

The addition of 6S to the nascent HS chain within the Golgi is mediated by a family of 6-O-sulfotransferases. Our data suggest that these modifications are fairly extensive throughout the chain (leading to approx. 40% of disaccharides containing 6S groups). It is the activity of the mSulf enzymes that reduces this level to the approx. 15%, which is found in HS prepared from tissues and which finalizes the complex sulfate patterning observed on mature HS chains.