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. 2006 Apr 6;108(6):1932–1940. doi: 10.1182/blood-2005-11-4404

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Copyright © 2006, The American Society of Hematology

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Figure 6. — DN-PACS-2 prevents degradation of newly synthesized CD31 by K5. (A) E-DMVECs were transduced with the indicated recombinant adenoviruses for 24 hours, and cell-surface expression of MHC I or CD31 was analyzed by flow cytometry (unshaded). Untreated cells stained for CD31 or MHC I are shown for comparison (shaded). Note that both CD31 and MHC I are down-regulated by K5, but only CD31 surface expression is restored upon cotransduction of DN-PACS-2. (B) Top panel shows immunoprecipitation of CD31 from E-DMVEC transduced with the indicated adenoviruses and metabolically labeled for 45 minutes (P) followed by a 3-hour chase. Bottom panel shows one-fourth of each sample immunoprecipitated using lamin A/C antibody as a loading control.