Table 1.

Gene Ontology results showing enrichment of terms assigned to the secretase-like siRNA hits for biological process and cellular component

GO gene set	Gene set size	Overlap	P
Biological process (input, 32 genes)
β-amyloid metabolism	17	6	2.84 × 10−14
RNA splicing	285	7	5.22 × 10−8
Cell-fate commitment	55	3	1.91 × 10−5
Cellular component (input, 25 genes)
Spliceosome complex	92	5	2.69 × 10−8
Microtubule cytoskeleton	348	5	1.91 × 10−5