FIGURE 4.
CD and HSQC characterization of viral hemagglutinin RBD. (a) Three-dimensional structure of the RBD in the context of the entire hemagglutinin molecule (PDB code 1JSN). (b and c) Far-UV CD and NMR HSQC spectra of the receptor binding domain (152 residues) dissected from the 561-residue hemagglutinin of the Avian Influenza A virus at pH 6.2 and 20°C. The protein concentration of the NMR sample was ∼400 μM. The HSQC peaks for nine Gly residues (including one from His-tag) are indicated by the arrow.