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Desensitization. (A) Time-course of activation of Fus3 (MAPK) in a wild-type cell (solid line) and in a mutant (dashed line). (B) Effect of feedback hyperphosphorylation of Ste7 in the scaffold. Predicted time-course activation of Fus3 for wild-type (solid line) and for mutants (dashed line and dotted line).
