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Montelukast significantly reduces airway hyperresponsiveness. Penh values were obtained from mice 24 hours after the last challenge in response to nebulized MCh via whole body plethysmography. The data are expressed as the mean ± SEM of Penh values (n = 3–4) as the increased percentage of baseline observed after PBS nebulization. * p < 0.05 and ** p < 0.01 when compared to PBS-treated group.
