Fig. 1: ypical ¹H-MR spectrum acquired from a 2 × 3 × 3-cm voxel located in the medial frontal cortex, with STEAM timings optimized for glutamate (TE, TM = 240, 27 ms). (a) 2Hz exponential filtered spectrum; (b) LCModel fit spectrum; (c) residual noise following subtraction of spectra in (a) and (b).