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. 1999 Apr 13;96(8):4488–4493. doi: 10.1073/pnas.96.8.4488

Figure 4.

Figure 4

Interactions of ARSs with the repeated sequences in IRS and EPRS. (A) Interactions of the peptide appendices in the complex-forming human ARSs were tested with the C-terminal region of IRS containing two repeats and flanking sequences (IRS–R12+ from E966 to F1,266) and the internal linker region of EPRS containing three repeats and flanking sequences (EPRS–R123+ from V573 to K889; ref. 15). (B) The N-terminal motifs of DRS and RRS were tested for interaction with the C-terminal region of IRS containing different repeats and flanking sequences (from top to bottom: E966–F1,266; S1,078–F1,266; E966–S1,077; S1,078–G1,161; and S1,169–F1,266). Incubation conditions were the same as described in Fig. 3.