Figure 5.
Effect of Rofecoxib (COX-2 inhibitor) and Valeryl Salicylate (COX-1 inhibitor) on the increase in hippocampal PGE2 seen at 2 h (A) and 24 h (B) after transient global cerebral ischemia in gerbils. In panel (C) is shown the effect of selective inhibition of COX-1 and COX-2 on the basal concentrations of PGE2 in the normal gerbil hippocampus. *p<0.05 and **p<0.01 with respect to vehicle-treated animals. In panel (C), *p<0.05 and **p<0.01 with respect to sham-vehicle group.