FIG. 1.
Topology model of the mannose transporter complex. His-10 and His-175 of IIABMan (ManX) transfer phosphate from phospho-HPr (PtsH) to the sugar that is translocated by the IIC/IID (ManY/ManZ) complex. The highly specific interaction between microcin E492 and the membrane-spanning IIC and/or IID subunit causes inner membrane depolarization. HPr is phosphorylated with phosphoenolpyruvate (PEP) by enzyme I (PtsI) of the phosphotransferase system. The model is predicted according to reference 18 with the constraints from references 11 and 13.