FIG. 8.

Models for the bactericidal mechanisms of endogenous MceA (A) and extracellular MccE492 (B). MceA and MccE492 are represented as black ellipses with protruding N-terminal signal sequences and C-terminal domains. OM, outer membrane; IM, inner membrane; YEG, SecYEG complex; C*, posttranslationally modified MccE492 C terminus. ±TrxA indicates that the bactericidal activity of endogenous MceA is not affected by the presence of a C-terminal TrxA domain. Instead of Δss-MceA, PhoA73-MceA was chosen here as an example of endogenous MceA. Details are described in the text.