FIG. 10.
Proposed catalytic cycle of phenylphosphate synthase. The phosphorylation site is that of histidine 569. This hypothetical catalytic mechanism is analogous to the phosphoenolpyruvate synthase mechanism. The scheme shows the net phosphorylation of phenol catalyzed by combined action of protein 1 and protein 2 and the partial reaction, the exchange of free [14C]phenol, and the phenol moiety of phenylphosphate (exchange reaction), catalyzed by protein 1 alone. Note that the role of protein 3 is not explained by this scheme and is elusive.