TABLE 2.
Function group and ORF (N315) | P value by t testa | Fold changeb | Description |
---|---|---|---|
Adaptation to atypical conditions | |||
SA0147 | 0.00 | 3.16 | Capsular polysaccharide synthesis Cap5D |
SA0144 | 0.00 | 3.60 | Capsular polysaccharide synthesis Cap5A |
SA1549 | 0.00 | 2.64 | Hypothetical protein similar to serine proteinase Do heat shock protein HtrA |
SA0145 | 0.00 | 2.65 | Capsular polysaccharide synthesis Cap5B |
SA2494 | 0.00 | 3.05 | Cold shock protein |
SA1096 | 0.00 | 2.23 | Heat shock protein |
SA0146 | 0.00 | 2.89 | Capsular polysaccharide synthesis Cap8C |
SA2336 | 0.00 | 2.30 | ATP-dependent Clp proteinase chain ClpL |
SA0148 | 0.01 | 2.60 | Capsular polysaccharide synthesis Cap8E |
SA0150 | 0.03 | 2.04 | Capsular polysaccharide synthesis Cap5G |
SA0149 | 0.03 | 2.14 | Capsular polysaccharide synthesis Cap5F |
Antibiotic production | |||
SA0173 | 0.01 | 2.19 | Hypothetical protein similar to surfactin synthetase |
Cell wall | |||
SA1691 | 0.00 | 3.52 | Hypothetical protein similar to protein 1A/1B |
SA1283 | 0.00 | 2.14 | Penicillin-binding protein 2 |
SA1024 | 0.00 | 2.32 | Penicillin-binding protein 1 |
Membrane bioenergetics (electron transport chain and ATP synthase) | |||
SA0411 | 0.00 | 5.00 | NADH dehydrogenase subunit |
SA0211 | 0.00 | 0.10 | Hypothetical protein similar to NADH-dependent dehydrogenase |
SA0210 | 0.00 | 0.13 | Hypothetical protein similar to NADH-dependent dehydrogenase |
SA0366 | 0.00 | 0.38 | Alkyl hydroperoxide reductase C |
SA0938 | 0.01 | 2.13 | Cytochrome d ubiquinol oxidase subunit II homologue |
SA1132 | 0.02 | 2.34 | Hypothetical protein similar to ferredoxin oxidoreductase beta subunit |
SA0937 | 0.02 | 2.14 | Cytochrome d ubiquinol oxidase subunit I homologue |
SA1311 | 0.02 | 2.12 | Hypothetical protein similar to thioredoxin reductase homologue |
SA1315 | 0.03 | 2.31 | Ferredoxin |
Metabolism of amino acids and related molecules | |||
SA2428 | 0.00 | 4.96 | Arginine deiminase |
SA2341 | 0.00 | 0.38 | 1-Pyrroline-5-carboxylate dehydrogenase |
SA1165 | 0.00 | 0.39 | Threonine synthase |
SA1166 | 0.00 | 0.39 | Homoserine kinase homologue |
SA0419 | 0.01 | 2.13 | Cystathionine gamma-synthase |
SA0416 | 0.01 | 2.05 | Hypothetical protein similar to carboxylesterase |
SA2427 | 0.02 | 4.24 | Ornithine transcarbamoylase |
SA2389 | 0.03 | 2.06 | Truncated hypothetical protein similar to metalloproteinase Mpr precursor |
Metabolism of carbohydrates and related molecules | |||
SA1142 | 0.00 | 5.46 | Aerobic glycerol-3-phosphate dehydrogenase |
SA0945 | 0.00 | 0.35 | Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex E2 |
SA1245 | 0.00 | 0.20 | 2-Oxoglutarate dehydrogenase E1 |
SA2008 | 0.00 | 3.40 | Alpha-acetolactate synthase |
SA0730 | 0.00 | 2.38 | Phosphoglycerate mutase |
SA1184 | 0.00 | 0.34 | Aconitate hydratase |
SA1244 | 0.00 | 0.26 | Dihydrolipoamide succinyltransferase |
SA1141 | 0.00 | 2.57 | Glycerol kinase |
SA0728 | 0.00 | 2.43 | Phosphoglycerate kinase |
SA2007 | 0.00 | 2.68 | Hypothetical protein similar to alpha-acetolactate decarboxylase |
SA0729 | 0.00 | 2.16 | Triosephosphate isomerase |
SA0182 | 0.00 | 0.36 | Hypothetical protein similar to indole-3-pyruvate decarboxylase |
SA1553 | 0.00 | 0.33 | Formyltetrahydrofolate synthetase |
SA1089 | 0.00 | 0.38 | SucD succinyl coenzyme A synthetase alpha chain |
SA2327 | 0.00 | 2.27 | Hypothetical protein similar to pyruvate oxidase |
SA1554 | 0.00 | 0.30 | Acetyl coenzyme A synthetase |
SA0232 | 0.00 | 40.16 | l-Lactate dehydrogenase |
SA0219 | 0.01 | 2.22 | Formate acetyltransferase activating enzyme |
SA0654 | 0.02 | 2.40 | Fructose 1-phosphate kinase |
SA1517 | 0.02 | 0.39 | Isocitrate dehydrogenase |
Metabolism of coenzymes and prosthetic groups | |||
SA1492 | 0.00 | 2.06 | Delta-aminolevulinic acid dehydratase |
Metabolism of nucleotides and nucleic acids | |||
SA0923 | 0.00 | 0.22 | Phosphoribosylformylglycinamidine cycloligase PurM |
SA0924 | 0.00 | 0.23 | Phosphoribosylglycinamide formyltransferase |
SA0921 | 0.00 | 0.24 | Phosphoribosylformylglycinamidine synthetase PurL |
SA0922 | 0.00 | 0.26 | Phosphoribosylpyrophosphate amidotransferase PurF |
SA0916 | 0.00 | 0.28 | Hypothetical protein similar to phosphoribosylaminoimidazole carboxylase PurE |
SA0925 | 0.00 | 0.27 | Bifunctional purine biosynthesis PurH |
SA0920 | 0.00 | 0.34 | Phosphoribosylformylglycinamidine synthase II |
SA2297 | 0.00 | 2.63 | Hypothetical protein similar to GTP-pyrophosphokinase |
SA0373 | 0.00 | 0.32 | Xanthine phosphoribosyltransferase |
SA0918 | 0.01 | 0.39 | Phosphoribosylaminoimidazolesuccinocarboxamide synthetase homologue |
Metabolism of phosphate | |||
SA2301 | 0.00 | 2.27 | Hypothetical protein similar to alkaline phosphatase |
No similarity | |||
SA2221 | 0.00 | 3.60 | Hypothetical protein |
SA1476 | 0.00 | 5.66 | Hypothetical protein |
SA2011 | 0.00 | 4.10 | Hypothetical protein |
SA2272 | 0.00 | 2.05 | Hypothetical protein |
SA1774 | 0.00 | 2.29 | (Bacteriophage phiN315) hypothetical protein |
SA0536 | 0.00 | 3.20 | Hypothetical protein |
SA2091 | 0.00 | 0.26 | Hypothetical protein |
SA1773 | 0.00 | 2.26 | (Bacteriophage phiN315) hypothetical protein |
SA1772 | 0.00 | 2.48 | (Bacteriophage phiN315) hypothetical protein |
SA1703 | 0.00 | 3.22 | Hypothetical protein |
SA0535 | 0.01 | 2.47 | Hypothetical protein |
SA0885 | 0.02 | 2.12 | Hypothetical protein |
SA2113 | 0.03 | 2.25 | Hypothetical protein |
SAS014 | 0.03 | 2.22 | Hypothetical protein |
SA2268 | 0.04 | 2.16 | Hypothetical protein |
Pathogenic factors (toxins and colonization factors) | |||
SA0587 | 0.00 | 0.13 | Lipoprotein streptococcal adhesin PsaA |
SA2430 | 0.00 | 2.37 | Zinc metalloproteinase aureolysin |
SA2206 | 0.00 | 0.29 | Immunoglobulin G-binding protein SBI |
SA0390 | 0.00 | 3.81 | (Pathogenicity island SaPIn2) 14 |
SA2097 | 0.01 | 2.68 | Hypothetical protein similar to secretory antigen precursor SsaA |
SA0742 | 0.01 | 2.14 | Fibrinogen-binding protein A |
SA2356 | 0.02 | 2.12 | Immunodominant antigen A |
Phage-related functions | |||
SA1796 | 0.00 | 6.74 | (Bacteriophage phiN315) hypothetical protein |
SA1782 | 0.00 | 2.86 | (Bacteriophage phiN315) hypothetical protein |
SA1785 | 0.00 | 2.04 | (Bacteriophage phiN315) hypothetical protein |
SA1783 | 0.01 | 2.38 | (Bacteriophage phiN315) hypothetical protein |
SA1788 | 0.02 | 2.03 | (Bacteriophage phiN315) hypothetical protein |
SA1775 | 0.02 | 2.31 | (Bacteriophage phiN315) hypothetical protein |
SA1797 | 0.02 | 2.12 | (Bacteriophage phiN315) hypothetical protein |
Protein folding | |||
SA1659 | 0.00 | 2.89 | Peptidyl-prolyl cis/trans isomerase homologue |
RNA modification | |||
SA1713 | 0.02 | 2.10 | RNA methyltransferase homologue |
SA1885 | 0.02 | 2.13 | Hypothetical protein similar to RNA helicase |
RNA synthesis | |||
SA2424 | 0.00 | 9.18 | Hypothetical protein similar to transcription regulator Crp/Fnr family protein |
SA2092 | 0.00 | 0.20 | Hypothetical protein similar to transcription regulator |
SA1949 | 0.00 | 4.15 | Lytic regulatory protein truncated with Tn554 |
SA1956 | 0.00 | 3.35 | Lytic regulatory protein truncated with Tn554 |
SA1700 | 0.00 | 4.09 | Two-component response regulator |
SA2429 | 0.00 | 3.61 | Hypothetical protein similar to arginine repressor |
SA0108 | 0.00 | 0.30 | Staphylococcal accessory regulator A |
SA2296 | 0.00 | 2.71 | Hypothetical protein similar to transcriptional regulator MerR family |
SA2103 | 0.00 | 2.20 | Hypothetical protein similar to divergon expression attenuator LytR |
SA1139 | 0.00 | 2.11 | Glycerol uptake operon regulatory protein |
SA0653 | 0.00 | 2.82 | Hypothetical protein similar to repressor of fructose operon |
SA1961 | 0.00 | 2.26 | Hypothetical protein similar to transcription antiterminator BglG family |
SA2418 | 0.01 | 2.18 | Hypothetical protein similar to response regulator |
SA0187 | 0.01 | 0.39 | Hypothetical protein similar to transcription regulator |
SA2295 | 0.03 | 2.65 | Gluconate operon transcriptional repressor |
SA2287 | 0.03 | 2.06 | Staphylococcal accessory regulator A |
Sensors (signal transduction) | |||
SA1701 | 0.00 | 4.09 | Two-component sensor histidine kinase |
SA1653 | 0.00 | 2.03 | Signal transduction protein |
SA2417 | 0.01 | 2.15 | Hypothetical protein similar to sensor histidine kinase |
Similar to unknown proteins | |||
SA0175 | 0.00 | 5.39 | Conserved hypothetical protein |
SA1702 | 0.00 | 3.31 | Conserved hypothetical protein |
SA0412 | 0.00 | 5.20 | Conserved hypothetical protein |
SA0213 | 0.00 | 0.23 | Conserved hypothetical protein |
SA2220 | 0.00 | 3.26 | Conserved hypothetical protein |
SA0413 | 0.00 | 2.83 | Conserved hypothetical protein |
SA0212 | 0.00 | 0.14 | Conserved hypothetical protein |
SA0588 | 0.00 | 0.13 | Conserved hypothetical protein |
SA2329 | 0.00 | 3.96 | Conserved hypothetical protein |
SA1712 | 0.00 | 3.19 | Conserved hypothetical protein |
SA0908 | 0.00 | 3.66 | Conserved hypothetical protein |
SA2146 | 0.00 | 2.72 | TcaA protein |
SA0919 | 0.00 | 0.31 | Conserved hypothetical protein |
SA0725 | 0.00 | 2.75 | Conserved hypothetical protein |
SA1021 | 0.00 | 2.33 | Conserved hypothetical protein |
SA1031 | 0.00 | 2.67 | Conserved hypothetical protein |
SA1032 | 0.00 | 2.17 | Conserved hypothetical protein |
SA0824 | 0.00 | 2.29 | Conserved hypothetical protein |
SA1433 | 0.01 | 0.37 | Conserved hypothetical protein |
SA0301 | 0.01 | 0.40 | Conserved hypothetical protein |
SA0962 | 0.01 | 2.08 | Conserved hypothetical protein |
SA1033 | 0.02 | 2.38 | Conserved hypothetical protein |
SA2481 | 0.02 | 2.23 | Conserved hypothetical protein |
SA0415 | 0.02 | 2.16 | Conserved hypothetical protein |
SA2298 | 0.03 | 2.01 | Conserved hypothetical protein |
SA0174 | 0.04 | 2.01 | Conserved hypothetical protein |
SA1071 | 0.04 | 2.02 | Conserved hypothetical protein |
Transport/binding proteins and lipoproteins | |||
SA2426 | 0.00 | 16.29 | Arginine/ornithine antiporter |
SA0541 | 0.00 | 4.96 | Hypothetical protein similar to amino acid transporter |
SA1140 | 0.00 | 5.59 | Glycerol uptake facilitator |
SA1960 | 0.00 | 3.85 | PTS mannitol-specific IIBC component |
SA0293 | 0.00 | 3.77 | Hypothetical protein similar to formate transporter NirC |
SA2156 | 0.00 | 3.72 | Permease LctP homologue |
SA0589 | 0.00 | 0.11 | Hypothetical protein similar to ABC transporter ATP-binding protein |
SA2303 | 0.00 | 0.21 | Hypothetical protein similar to membrane-spanning protein |
SA0208 | 0.00 | 0.13 | Maltose/maltodextrin transport permease homologue |
SA2302 | 0.00 | 0.31 | Hypothetical protein similar to ABC transporter |
SA0111 | 0.00 | 0.38 | Lipoprotein |
SA0848 | 0.00 | 0.35 | Oligopeptide transport system ATP-binding OppF homologue |
SA2167 | 0.00 | 2.69 | PTS sucrose-specific component |
SA0207 | 0.00 | 0.21 | Hypothetical protein similar to maltose/maltodextrin-binding protein |
SA0849 | 0.00 | 0.35 | Hypothetical protein similar to binding protein OppA |
SA0432 | 0.00 | 2.52 | PTS enzyme II, phosphoenolpyruvate dependent, trehalose specific |
SA0209 | 0.00 | 0.20 | Maltose/maltodextrin transport permease homologue |
SA0206 | 0.00 | 0.20 | Multiple sugar-binding transport protein |
SA0640 | 0.00 | 2.01 | Hypothetical protein similar to ABC transporter required for expression of cytochrome bd |
SA0172 | 0.00 | 2.19 | Hypothetical protein similar to membrane protein LmrP |
SA0186 | 0.00 | 0.38 | Hypothetical protein similar to phosphotransferase enzyme II |
SA0639 | 0.01 | 2.04 | Hypothetical protein similar to ABC transporter required for expression of cytochrome bd |
SA0531 | 0.01 | 2.20 | Proline/betaine transporter homologue |
SA0417 | 0.01 | 2.15 | Hypothetical protein similar to sodium-dependent transporter |
SA0655 | 0.01 | 2.25 | Fructose-specific permease |
SA0374 | 0.01 | 0.39 | Xanthine permease |
SA2053 | 0.01 | 2.06 | Glucose uptake protein homologue |
SA2434 | 0.02 | 2.31 | Fructose phosphotransferase system enzyme homologue |
Only ORFs with a P value by t test of <0.05 have been listed.
Only ORFs with a fold change of <0.4 or ≥2.0 for the hemB mutant versus the parent strain have been listed.