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. 2006 Sep 22;34(18):5157–5165. doi: 10.1093/nar/gkl667

Figure 7.

Figure 7

Indolicidin inhibits Top1 catalytic activity but does not intercalate into DNA. (A) native supercoiled φX174 DNA (lane 1) was incubated with Top1 in the absence of indolicidin (lane 2) or in the presence of indicated concentrations of indolicidin (lanes 3–7). (B) Native supercoiled φX174 DNA (lane 1) was first reacted with excess Top1 to fully relax the DNA in the absence of indolicidin (lane 2). Samples were then further incubated with the indicated concentrations of indolicidin (lanes 3–7).