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Thermodynamic cycle of free energy exchanges. ΔGdisruption is the target disruption energy, which measures the free energy cost to open the secondary structure at the target site; ΔGoligo is the self-folding minimal free energy (MFE) of the antisense oligo; ΔGhybrid is the binding energy (stability) for the hybrid formed between the antisense oligo and the target site.
