Fig. 4.

Autoantibodies present in sera of r1ΔT/r2n mice. (A) Serum reactivity in 3- to 12-month-old Cre⁺ mice and littermates was tested in an ANA stain of the human epithelial line HEp-2. Serum was tested at a dilution of 1:160 according to the manufacturer's instructions. The ratio of ANA-positive sera to total mice tested is indicated. (B) Titer of anti-SS-A levels in the sera of mice from 3 to 8 months of age. Each point represents serum levels from one mouse. The horizontal bars represent the mean. ∗∗, P < 0.01. (C) Serum from one pair of older mice (12 months) reveals a much more dramatic difference in anti-SS-A (Left) and anti-SS-B levels (Right).