Figure 8.

Schema of Ang II-induced NFAT activation in cardiac myocytes. In cardiac myocytes, stimulation of AT1R induces NFAT activation through Gα_q-PLC signaling pathway. DAG, generated by PLC activation, directly activates TRPC3 and TRPC6 (TRPC3/C6). Activation of TRPC3/C6 causes slow increases in the membrane potential to a positive direction (ΔΨ) and concomitantly increases the frequency of spontaneous firing due to activation of L-type Ca²⁺ channel. The Ca²⁺ influx though L-type Ca²⁺ channel activates calcineurin-NFAT pathway, which leads to hypertrophic responses in cardiomyocytes.