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Early deletion of Six3 downregulates Pax6 preplacodal expression. Ubiquitous, early deletion of Six3 by injection of tamoxifen at E7.8 and E8.5 in Six3f/Δ;CAGG-Cre-ER mutant embryos analyzed at E9.0 (18-somite stage). (A′, D′) Six3 activity was almost completely removed from the PLE (arrowheads) and optic vesicle. Pax6 (B′, E′) and Sox2 (C′, F′) expression was reduced in the PLE, although with varying efficiency.
