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. 2006 Nov 17;2(11):e154. doi: 10.1371/journal.pcbi.0020154

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© 2006 Andrews et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Comparison of the step response of the E. coli signaling network model to the response of the linearized form of the model shows that the linearization is valid for even moderately large step changes in attractant. Response shown is for a step ligand change from L = 1 μM to L = 2 μM (A), 10 μM (B), 50 μM (C), and 100 μM (D), with the linearization about the ligand value L ₀ = 1 μM. Model parameters are the same as in Figure 9.