Table 1.
Genes significantly up-regulated by PCN
| Fold Change | Gene/Description | Gene Symbol | GenBank Accession No. | Group |
|---|---|---|---|---|
| 10.36 | Growth arrest and DNA-damage-inducible 45 beta | Gadd45β | NM_001008321 | Binding-protein |
| 5.92 | Moderate similarity to p53-associated protein (H. sapiens) | MDM2 | CAA78055 | Binding-protein |
| 4.28 | Cytochrome P45026, retinoic acid | Cyp26 | NM_130408 | Metabolism
Transport-electron |
| 4.01 | Moderate similarity to suppression of tumorigenicity 5 | St5 | NM_005418 | Signal transduction
Tumor suppression |
| 3.67 | Aminolevulinic acid synthase 1 | Alas1 | NM_024484 | Metabolism-heme biosynthesis |
| 3.07 | P450 (cytochrome) oxidoreductase | Por | NM_031576 | Transport-electron |
| 2.74 | Moderate similarity to Ras association, domain family1 (H. sapiens) | RALGDS/AF6 | NM_007182 | Signal transduction
Tumor suppression |
| 2.74 | Cytochrome P450, 3a18 | Cyp3a18 | NM_145782 | Metabolism
Transport- electron |
| 2.55 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | Abcc3 | NM_080581 | Binding-ATP
Transport |
| 2.45 | Moderate similarity to HUMAN sorting nexin 8 | SNX8 | NM_013321 | Intracellular signaling
Transport- protein |
| 2.40 | Similar to B-cell leukemia/lymphoma 3 (predicted) | Bcl3 (predicted) | XM_214856 | Cell cycle |
| 2.35 | Moderate similarity to yeast Sec31p homolog (H. sapiens) | SEC31p | NM_199530 | Unknown |
| 2.28 | Strong similarity to HUMAN calcium-binding mitochondrial carrier protein | SLC25A12 | NM_003705 | Binding-calcium ion
Transport |
| 2.24 | Similar to retinol dehydrogenase 10 (all-trans) [Mus musculus] | Rdh10 | NM_133832 | Oxidoreductase activity |
| 2.08 | ATP-binding cassette, sub-family B (MDR/TAP), member 1A | Abcb1a | NM_133401 | Binding-ATP
Transport |
| 2.03 | GTP cyclohydrolase 1 | Gch | NM_024356 | Hydrolase activity |
| 1.90 | Lactamase, beta 2 | Lactb2 | NM_00102427 | Unknown |
| 1.85 | Cyclin D1 | Ccnd1 | NM_171992 | Binding-protein
Cell cycle |
| 1.84 | Strong similarity to HUMAN ARL-6 interacting protein-2 | ARL6 | NM_032146 | Hydrolase activity
Binding-protein |
| 1.83 | BCL2/adenovirus E1B 19 kDa-interacting protein 3-like | Bnip3 | NM_053420 | Apoptosis |
| 1.79 | Liver UDP-glucuronosyltransferase, phenobarbital-inducible form | Ugt2b3 | NM_153314 | Metabolism-glucuronosy transferase |
| 1.78 | Strong similarity to mitogen inducible gene mig-2 (H. sapiens) | PLEKHC1 | Z24725 | Binding-protein |
| 1.78 | Protein phosphatase 2a, catalytic subunit, beta isoform | Ppp2cb | NM_017040 | Protein phosphatase |
| 1.74 | DnaJ homolog, subfamily b, member 9 | Dnajb9 | NM_012699 | Protein binding-heat shock |
| 1.71 | Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase | Mgat2 | NM_053604 | Transferase activity |
| 1.69 | PDZ domain containing 1 | Pdzk2 | NM_133226 | Binding-Protein
Intracellular signalling |
| 1.69 | Tumor necrosis factor receptor superfamily, member 1a | Tnfrsf1a | NM_013091 | Receptor activity
Intracellular signalling |
| 1.67 | Glutathione S-transferase, mu 1 | Gstm1 | NM_017014 | Metabolism-glutathione |
| 1.67 | Purinergic receptor P2Y, G-protein coupled 2 | P2ry2 | NM_017255 | Binding-nucleotide |
| 1.66 | BCL2/adenovirus E1B 19 kDa-interacting protein 3-like | Bnip3l | NM_053420 | Apoptosis |
| 1.63 | Phospholipase A2, activating protein | Plaa | NM_053866 | Metabolism-phospholipid |
| 1.62 | TERF1 (TRF1)-interacting nuclear factor 2 | Tinf2 | NM_001006962 | Binding-protein |
| 1.60 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Abcc2 | NM_012833 | Binding-ATP
Transport |
| 1.58 | RAB2, member RAS oncogene family | Rab2 | NM_031718 | Binding-nucleotide
Protein transport |
| 1.55 | Cytochrome P450, subfamily 3A, polypeptide 3 | Cyp3a3 | NM_013105 | Metabolism
Transport-electron |
| 1.55 | Heat shock 22kDa protein 8 | Hspb8 | NM_053612 | Protein binding-heat shock |
| 1.53 | Valosin-containing protein (p97)/p47 complex-interacting protein p135 | Ycip135 | NM_176857 | Binding-protein |
| 1.52 | Proteasome (prosome, macropain) 26S subunit, non-ATPase 4 | Psmd4 | NM_031331 | Transport-fluid |
| 1.49 | Moderate similarity to mitochondrial ribosomal protein L11 (H.sapiens) | MRPL11 | NM_016050 | Structural constituent of ribosome |
| 1.48 | Moderate similarity to elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 (H.sapiens) | ELOVL1 | NM_022821 | Fatty acid biosynthesis |
| 1.47 | Sjogren syndrome antigen B | Ssb | NM_031119 | Binding-RNA |
| 1.46 | Eukaryotic translation initiation factor 4 gamma, 1 (predicted) | Eif4g1 (predicted) | XM_213569 | Binding-RNA
Protein biosynthesis |
| 1.44 | t-Complex protein 1 | Tcp1 | NM_012670 | Binding-nucleotide
Protein folding |
| 1.44 | Lectin, galactose binding, soluble 3 | Lgals3 | NM_031832 | Binding-protein
Cell adhesion |
| 1.41 | Similar to SAR1a gene homolog mRNA | Sara1 | NM_001007739 | Binding-nucleotide |
| 1.40 | RAB6, member RAS oncogene family | Rab6 | XM_574503 | ATPase/GTPase activity |
| 1.38 | Moderate similarity to Poly(A) polymerase alpha (PAP) (H. sapiens) | PAPOLA | NM_032632 | Binding-RNA
Transferase activity |
| 1.37 | Fibronigen-like protein 1 | Fgl1 | NM_172010 | Cell growth |
| 1.33 | Strong similarity to small GTP-binding protein; RAB1B, member RAS oncogene family (H.sapiens) | RAB1B | NM_030981 | Binding-nucleotide
Signal transduction |
| 1.32 | Heterogeneous nuclear ribonucleoprotein U | Hnrpu | NM_057139 | Binding-nucleotide
RNA processing |
| 1.29 | Eukaryotic translation initiation factor 2, subunit 1 (alpha ) | Eif2s1 | NM_019356 | Binding-nucleic acid
Binding-protein Protein biosynthesis |
| 1.27 | DnaJ (Hsp40) homolog, subfamily A, member 2 | Dnaja2 | NM_032079 | Protein binding-heat shock |
| 1.26 | Leukocyte cell-derived chemotaxin 2 (predicted) | Lect2 (predicted) | XM_341486 | Metalloendopeptidase activity
Chemotaxis |