Table 2.
Genes significantly down-regulated by PCN
| Fold Change | Gene/Description | Gene Symbol | GenBank Accession No. | Group |
|---|---|---|---|---|
| −1.19 | Non-metastatic cell expressed protein 3 (nucleoside diphosphate kinase) | Mne3 | NM_053507 | Kinase activity
Nucleotide biosynthesis |
| −1.25 | Death-associated protein | Dap | NM_022526 | Apoptosis |
| −1.27 | RNA terminal phosphate cyclase domain 1 | Rtcd1 | NM_001004227 | Metabolism-RNA |
| −1.28 | Cytochrome P450 monooxygenase | Cyp2t1 | NM_134369 | Cytochrome-electron transport |
| −1.32 | Apoptotic peptidase activating factor 1 | Apaf1 | NM_023979 | Apoptosis |
| −1.35 | Low density lipoprotein receptor-related protein 11 (predicted) | Lrp11 (predicted) | XM_238072 | Receptor activity
Endocytosis |
| −1.35 | Ras homolog gene family, member E | Arhe | NM_001007641 | Binding-GTP |
| −1.39 | Dipeptidylpeptidase 4 | Dpp4 | NM_012789 | Catalytic activity aminopeptidase |
| −1.39 | Cytochrome P450, subfamily 2F, polypeptide 1 | Cyp2f1 | NM_019303 | Cytochrome-electron transport |
| −1.41 | Kinesin family member C2 | Kifc2 | NM_198752 | Binding -ATP
Microtubule motor activity |
| −1.41 | Acyl-CoA synthetase long-chain family member 4 | Acsl4 | NM_053623 | Catalytic activity
Metabolism-fatty acid |
| −1.43 | Glutamate dehydrogenase 1 | Glud1 | NM_012570 | Binding-nucleotide
Metabolism-amino acid |
| −1.45 | Moderate similarity to B-cell CLL/lymphoma 7A (H.sapiens) | BCL7A | NM_020993 | Actin binding |
| −1.49 | Methylmalonyl CoA epimerase (predicted) | Mcee (predicted) | XM_215213 | Metabolism- L-methylmalonyl-CoA |
| −1.59 | Carbonic anhydrase 2 | Ca2 | NM_019291 | Carbonic anhydrase activity |
| −1.61 | Liver glycogen phosphorylase | Pygl | NM_022268 | Catalytic activity
Metabolism-carbohydrate |
| −1.75 | Matrilin 1, cartilage matrix protein | Matn1 | NM_001006979 | Structure-extracellular |
| −1.79 | Aquaporin 8 | Aqp8 | NM_019158 | Transport-water |
| −1.79 | Aquaporin 9 | Aqp9 | NM_022960 | Transport-amine
Canalicular bile acid |
| −1.92 | Rab38, member of RAS oncogene family | Rab38 | NM_145774 | Binding-nucleotide
Transport-protein |
| −1.92 | Arginine vasopressin receptor 1A | Avpr1a | NM_053019 | G-protein coupled receptor activity |
| −2.04 | CTL target antigen | Cth | NM_017074 | Metabolism-amino acid |
| −2.04 | Strong similarity to secreted modular calcium-binding protein1 (H. sapiens) | SMOC1 | NM_001034852 | Binding-calcium ion |
| −2.08 | Similar to NOGO-interacting mitochondrial protein (H. sapiens) | RTN4IP1 | NM_032730 | Oxidoreductase activity |
| −2.27 | Glrx1 glutaredoxin 1 (thioltransferase) | Glrx 1 | NM_022278 | Transport-electron |
| −2.38 | Moderate similarity to protein vitrin (H. sapiens) | VIT | NP_444506 | Unknown |
| −2.50 | Myotubularin related protein 7 | Mtmr7 (predicted) | XM_240417 | Actin binding
Phospholipid dephosphorylation |
| −3.85 | Claudin 1 | Cldn1 | NM_031699 | Binding-protein |
| −7.14 | Low density lipoprotein receptor-related protein 5 (predicted) | Lrp5 (predicted) | XM_215187 | Receptor activity |