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. 2006 Nov 17;2(11):e187. doi: 10.1371/journal.pgen.0020187

Figure 11. The C. neoformans Mac1 Protein Is Polymorphic.

Figure 11

Translated amino acid sequences for Mac1 from strains B3501α and JEC21α (congenic to B3502a) are depicted. CNG02270 contains a copper-fist DNA binding domain at the N-terminus that is conserved between copper-regulating transcription factors, such as Mac1 of S. cerevisiae and Cuf1 of S. pombe. It also shares a copper-binding motif at the C-terminal region with S. pombe Cuf1 (328–342aa) that is important for activity.

^, sequences underlined with this mark are the predicted copper-Fist DNA binding domain.

#, cysteine and histidine residues conserved between Cuf1 of S. pombe and Mac1 of C. neoformans.

Cn, C. neoformans; Sc, S. cerevisiae; Sp, S. pombe.