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. 2006 Aug 21;26(21):7892–7900. doi: 10.1128/MCB.00968-06

FIG. 2.

FIG. 2.

Effect of lckW97A allele on positive selection in TCR transgenic mice. lckW97A mice were crossed with mice expressing the OT-II, H-Y, and OT-I TCR transgenes, and thymocytes from lck+ and lckW97A littermates were analyzed by flow cytometry. Data are representative of 3 to 5 different experiments with each line. (A) Expression of CD4 and CD8 on thymocytes from OT-II transgenic mice. (B) Expression of CD4 and CD8 on H-Y receptor expressing thymocytes from female mice. Data are gated on thymocytes staining with the H-Y clonotype-specific antibody T3.70. (C) Expression of CD4 and CD8 on thymocytes from OT-I transgenic mice. Data are gated on thymocytes staining with high levels of antibody specific for receptors containing Vα2, a component of the OT-I TCR.