TABLE 2.
Blood data for 8-week-old Hspa4l−/− and Hspa4+/+ mice treated with 3% NaCl in drinking watera
| Genotype and group (n) | pH | pCO2 (mm Hg) | pO2 (mm Hg) | Concn in plasma (mmol/liter)
|
Hematocrit (%) | Blood urea nitrogen (mg/dl) | ||
|---|---|---|---|---|---|---|---|---|
| Na+ | Ca2+ | K+ | ||||||
| +/+ (7) | 7.29 ± 0.04 | 60.79 ± 5.73 | 40.73 ± 3.97 | 160.02 ± 7.92 | 1.3 ± 0.04 | 7.18 ± 0.59 | 45.43 ± 3.99 | 28.25 ± 4.82 |
| −/− | ||||||||
| Group I (3) | 7.08 ± 0.09** | 81.40 ± 16.19* | 67.03 ± 5.09** | 198.70 ± 16.21** | 1.67 ± 0.09** | 5.97 ± 1.47 | 41.63 ± 3.38 | 62.50 ± 1.41** |
| Group II (5) | 7.32 ± 0.05 | 53.87 ± 5.1 | 34.55 ± 6.2 | 157.57 ± 3.64 | 1.32 ± 0.03 | 7.55 ± 0.51 | 43.15 ± 0.64 | 17.40 ± 1.47* |
a
All values are means ± SD. Asterisks indicate that values for Hspa4l−/− mice are significantly different from those for Hspa4l+/+ mice (*, P < 0.01; **, P < 0.001 [Student's t test]). Groups I and II are susceptible and nonsusceptible Hspa4l−/− animals, respectively, with regard to treatment with 3% NaCl in their drinking water.