TABLE 2.

Activity and accumulation of v-Src and GR in mutant Hsp90 yeast strains^a

Yeast strain	Result for:
	v-Src			GR
	Cellular activity	Accumulation	Sp act	Cellular activity	Accumulation	Sp act
Wild-type	100	100	100	100	100	100
T22I	11.6	83.5 ± 11.9	13.9	1.1	11.7 ± 1.0	9.4
T101I	0.3	23.8 ± 9.4	1.3	0.2	115.6 ± 21.0	0.2
W300A	389.9	926.1 ± 84.0	42.1	61.4	118.0 ± 26.2	52.0
F329A/L331A/F332A	67.7	94.9 ± 8.4	71.3	71.4	77.9 ± 29.7	91.7
E381K	1.6	20.5 ± 2.8	7.8	0.8	10.9 ± 2.8	7.3
E431K	60.8	149.7 ± 52.7	40.6	9.1	7.9 ± 2.6	115.2
S485Y	40.4	26.6 ± 4.8	151.9	0.3	77.3 ± 13.0	0.4
T525I	76.8	28.7 ± 18.9	267.6	1.6	102.7 ± 15.6	1.6

^aValues are given as percentages of results for the wild type.