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. 2006 Sep 5;26(22):8228–8241. doi: 10.1128/MCB.01155-06

FIG. 5.

FIG. 5.

Sequence comparison of the destabilizing 3′UTR elements in IL-6 mRNA. The first 224 nucleotides of the 3′UTR of various species were aligned by ClustalW and the conservation of each position (below the alignment) analyzed by the JalView program (http://www.ebi.ac.uk/clustalw/index.html). The FGH and L regions as well as AUUUA sequences are highlighted. A possible stem and loop region in the FGH box is indicated. IL-6 mRNA species are from Oryctolagus cuniculus (GenBank accession no. AF169176), Sylvilagus nuttallii (AF169178), Sylvilagus audubonii (AF169177), Rattus norwegicus (NM_012589), Mus musculus (NM_031168), Marmota monax (AF012908), Homo sapiens (M54894), Ovis aries (X62501), Sus scrofa (M80258), Canis familiaris (U12234), Bos taurus (X57317), and Gallus gallus (AJ309540).