FIG. 3.

Analysis of iridocorneal angle morphology. (A to C) Light microscopy of H&E-stained sections of iridocorneal angles from Myoc^+/+, Myoc^Y423H/+, and Myoc^Y423H/Y423H mice was indistinguishable. The termini of Schlemm's canal are indicated with arrows, and the trabecular meshwork is indicated with arrowheads. AC, anterior chamber. Scale bar = 50 μm. (D to F) Transmission electron microscopy images of iridocorneal angles from Myoc^+/+, Myoc^Y423H/+, and Myoc^Y423H/Y423H mice were also indistinguishable. Images in panels D and F were chosen to show mild rER distention (see text). Collagen fibrils are marked with asterisks. SC, Schlemm's canal; ITS, open intertrabecular spaces. Scale bar = 500 μm.