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. 2006 Oct 2;26(23):9105–9115. doi: 10.1128/MCB.01452-06

FIG. 7.

FIG. 7.

CaMKKα KO mice show normal synaptic transmission and LTP. (A) WT and KO hippocampal slices show no significant difference in paired-pulse facilitation (PPF) of the EPSPs at various interpulse intervals (seven slices from five WT mice; seven slices from five KO mice). The insets show representative field EPSP traces with a paired-pulse interval of 50 ms. (B) WT and KO hippocampal slices show no significant difference in NMDA receptor-mediated EPSCs (six slices from five WT mice; five slices from five KO mice). The insets show example NMDA receptor-mediated EPSC traces at various stimulation intensities. (C) LTP is normal in CaMKKα KO mice. Two-train tetanic stimulation-induced LTP in the CA1 region of the hippocampus from WT mice (eight slices from five mice) and KO mice (three slices from three mice). The insets show representative field EPSP traces before and 45 min after tetanic stimulation.