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Altered metabolic rate in Nfatc2−/− Nfatc4−/− mice. Oxygen consumption (VO2) (A and B), carbon dioxide production (VCO2) (C and D), heat production (E and F), and locomotor activity (G and H) of Nfatc2−/− Nfatc4−/− (DKO) and control mice (n = 8) were measured using an indirect open-circuit calorimeter system.
