FIG. 10.

Diagram depicting cell cycle-dependent AML1 degradation by the APC/C or SCF complexes. Our data support the idea that AML1 phosphorylated at positions 276, 293, 300, and 303 is targeted for degradation by the APC-Cdc20 complex at early M phase. The APC-Cdh1 complex active during the late M and G₁ phases is able to degrade AML1 independent of phosphorylation status. During reentry of the cells into S phase, the SCF-Skp2 complex slightly degrades phosphorylated AML1. This suggests a mechanism for the regulation of AML1 protein levels (and activity) during cell cycle progression.