Table 2.
Immunophenotype of HHV-8-positive cells in MCD, compared to HHV-8-positive PEL cells
| mAbs | PEL cells (27, 28) | Parraviccini et al. (17) | Present study |
|---|---|---|---|
| T-cell markers | |||
| CD3 | neg | neg | neg |
| CD5 | neg | ND | neg |
| CD45RO | neg | neg | neg |
| B-cell markers | |||
| CD20 | neg | neg | + |
| CD79a | neg | ND | neg |
| CD10 | neg | ND | neg |
| Activation markers | |||
| CD23* | + | ND | neg |
| CD25 | + | ND | neg |
| CD30 | +/neg | neg | neg |
| CD38 | + | neg | neg |
| CD40 | neg | ND | neg |
| Follicular dendritic cells | |||
| CD21 | neg | ND | neg |
| Monocyte/macrophages | |||
| CD68 | ND | neg | neg |
| Others | |||
| CD43 | + | ND | neg |
| EMA | + | neg | neg |
| CD34 | ND | ND | neg |
| VEGFR-3 | ND | ND | neg |
*
CD23 also stains follicular dendritic cells; CD21 also stains B-cells. ND, not done; neg, negative; +; positive.