Table 1.

Antibody levels in rhesus monkeys before and after immunizations

4 μg Pfs25H-OMPC				40 μg Pfs25H-OMPC				40 μg Pfs25H/ISA51
D70	D84*	D584	D611*	D70	D84*	D584	D611*	D70	D84*	D584	D611*
				Anti-Pfs25 ELISA units in individual monkeys
1,080	4,780	1,970	8,040	3,370	16,620	5,450	30,670	110	1,740	1	1,380
870	5,570	1,290	9,950	5,040	11,830	9,720	23,680	7,730	21,120	810	9,510
1,970	17,080	1,580	13,990	4,120	16,650	3,220	18,590	3,260	15,980	780	15,360
6,070	48,360	5,500	91,780	2,130	6,990	1,440	12,380	9,050	32,650	2,780	19,280
2,000	5,650	1,820	7,560	—	—	—	—	1,660	6,900	760	6,210
				Geometric mean 95% confidence intervals
1,860	10,450	2,090	15,068	3,490	12,297	3,960	20,220	2,090	10,580	270	7,520
960–	4,360–	1,270–	6,060–	2,440–	8,230–	1,780–	13,860–	430–	3,830–	20–	3,010–
3,610	25,020	3,430	37,440	5,010	18,370	8,770	29,510	10,160	29,180	4,280	18,800
					Probability
<0.03		<0.03		<0.04		<0.04		<0.03		<0.03

The group names indicate the first two vaccinations on days 0 and 70. All three groups received 40 μg of Pfs25H/MAA as the third vaccination on day 596. Dn indicates the day number. Probability indicates the significance between antibody levels before and after the immunizations.

*Anti-Pfs25H ELISA units 2 weeks after the second immunization on day 70 or the third immunization on day 596.