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. Author manuscript; available in PMC: 2006 Nov 16.
Published in final edited form as: Immunol Rev. 2006 Oct;213:36–47. doi: 10.1111/j.1600-065X.2006.00436.x

Fig. 6. Inhibitory LILR cancel activating signals.

Fig. 6

Ligation of inhibitory LILR results in phosphorylation of their ITIM domains and recruitment of p56lckand SHP-1. This causes dephosphorylation of the ITAMS that would, in the absence of the inhibitory signals, drive cell activation. HLA-G interacts with inhibitory LILR. Modified from Brown et al.(66). ITAMS, immunoreceptor tyrosine-based activating motifs; ITIM, immunoreceptor tyrosine-based inhibitory motif; SHP-1, SH2-containing protein-tyrosine-phosphatase-1.