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(A) Schematic presentation showing the envelope region and V3 sequences of ConB and alanine328 mutants. ConB contains the consensus V3 sequence of HIV-1 subtype B in the backbone of an infectious molecular clone, HXB2RU3 (6). (B) Effect of amino acid substitutions to alanine328 on CCR5 utilization as measured by log reduction of p24 in virus-infected cultures. The log reduction of p24 between each alanine328 mutant and the wild type also is summarized in A.
