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Schematic drawing of the ternary complex consisting of gp120 core, two-domain CD4, and Fab fragment of 17b, as revealed by crystallographic study (8). A large gap was present between the base of V3 and light chain of 17b, a surrogate molecule of CCR5. The V3 loop is depicted as occupying this gap if there was an antigenic match. V3 residues identified to be critical for CCR5 interaction in this study are circled. BRS, bridging sheet; H.C., heavy chain; L.C., light chain.
