Table 4.
Inflammatory cytokine concentrations in airways from CF and wild-type (WT) mice at the indicated time points after a single dose of P aeruginosa LPS with and without pre-treatment with azithromycin (10 mg/kg/day), by oral administration, for 4 weeks.
| MIP-2 pg/ml | TNF-α pg/ml | IL-10 pg/ml | |||
| CF | LPS 3 h | AZM- | 3966.7 ± 230.3 | 4041.1 ± 347.6 | ND |
| AZM+ | 3800.8 ± 106.2 | 2648.1 ± 386.3* | ND | ||
| LPS 24 h | AZM- | 489.1 ± 20.4 | 282.3 ± 42.6 | ND | |
| AZM+ | 300.4 ± 35.9† | 251.9 ± 43.3 | ND | ||
| LPS 48 h | AZM- | 166.9 ± 19.6 | 40.5 ± 9.7 | 25.2 ± 3.2 | |
| AZM+ | 220.1 ± 26.9 | 14.2 ± 3.1* | 30.2. ± 4.4 | ||
| WT | LPS 3 h | AZM- | 3933.3 ± 264.6 | 3805.2 ± 355.6 | ND |
| AZM+ | 4254.2 ± 142.0 | 4368.5 ± 362.5 | ND | ||
| LPS 24 h | AZM- | 169.8 ± 35.3 | 368.9 ± 84.6 | ND | |
| AZM+ | 230.0 ± 31.9 | 361.6 ± 29.9 | ND | ||
| LPS 48 h | AZM- | 328.1 ± 13.5 | 114.9 ± 8.0 | 40.5 ± 6.4 | |
| AZM+ | 340.0 ± 10.1 | 111.0 ± 11.1 | 36.7 ± 2.2 | ||
Values are means ± SEM for 6–9 animals per each of the 12 subgroups from the same experiment as that used to generate Table 3. *p < 0.05; †p < 0.005 and ‡p < 0.0005 for comparison of corresponding mean value vs. that obtained for the same parameter at the same time point without pre-treatment with azithromycin. ND = below corresponding detectable levels.